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Schedule including this lecture.
Goddard Space Flight Center Engineering Colloquium
Date: Monday, November 19, 2001
For diabetic patients, monitoring glucose levels is literally a matter of life or death. Given the unpleasant method used today, it would have to be for anyone to do it. At Sensors for Medicine and Science, Inc. (SMSI), we have changed the monitoring paradigm from 'bringing the sample to the measuring device' to 'bringing the measuring device to the sample'. By implanting a microfluorimeter outfitted with both novel indicator chemistry and telemetry, we can monitor glucose levels in the interstitial fluid of rabbits from outside of the rabbit. As the platform engineering reaches perfection, the list of new applications will be limited only by chemists' ability to discover new chemosensor molecules.
Anthony W. Czarnik was born in Appleton, Wisconsin on November 21, 1957. He attended public schools in Appleton, Combined Locks, and Kimberly, Wisconsin, and received his B.S. (cum laude) from the University of Wisconsin-Madison in 1977. His undergraduate major was biochemistry, but he carried out undergraduate research during that time in two organic laboratories, at UW-Madison (with Prof. Vedejs) and at Argonne National Laboratory (with M. MacCoss). Dr. Czarnik received his graduate training at the University of Illinois at Urbana/Champaign, obtaining both an M.S. degree (1980) in Biochemistry and a Ph.D. (1981) in Organic Chemistry under the guidance of Prof. Nelson Leonard. From 1981-1983, he was an NIH Postdoctoral Fellow at Columbia University working with Prof. Ronald Breslow on the design of artificial enzymes. He began his academic career in 1983 at The Ohio State University, on the Faculty of the Department of Chemistry. Dr. Czarnik has received both DuPont and Merck awards for new faculty, and in 1986 was presented with an American Cyanamid award in recognition of excellence in the advancement of science and the art of chemical synthesis. He was named an Eli Lilly awardee in 1988, a Fellow of the Alfred P. Sloan Foundation in 1989, and a Teacher-Scholar Fellow of the Camille and Henry Dreyfus Foundation in 1990. He is currently serving as Editor of the ACS' "Journal of Combinatorial Chemistry", as Editor of Wiley's "Solid-Phase Organic Syntheses" book series, and on the Editorial Board of "Current Opinion in Chemical Biolog"y. He is author of over 100 scientific publications and an editor of seven books. From 1993 to 1996, Dr. Czarnik served as Director of BioOrganic Chemistry at Parke-Davis Pharmaceutical Research. In 1996, he accepted the position of Senior Director, then Vice President, Chemistry at IRORI Quantum Microchemistry in San Diego, CA. In 1998, Dr. Czarnik became a co-founder of Illumina, Inc. in San Diego, CA. He is currently serving as Chief Scientific Officer at Sensors for Medicine and Science, Inc. His current research interests include fluorescent chemosensors of ion and molecule recognition, combinatorial chemistry as a tool for drug discovery, and nucleic acids as targets for small molecule intervention.
Colloquium Committee Sponsor: Henning Leidecker
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